LOCUS HSCOMT2 3651 bp DNA linear PRI 18-APR-2005 DEFINITION H.sapiens gene for catechol O-methyltransferase. ACCESSION Z26491 VERSION Z26491.1 GI:403303 KEYWORDS catechol O-methyltransferase. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 975 to 3651) AUTHORS Tenhunen,J., Salminen,M., Lundstrom,K., Kiviluoto,T., Savolainen,R. and Ulmanen,I. TITLE Human catechol-O-methyltransferase: Genomic organization of the gene and its expression from two distinct promoters JOURNAL J. Biol. Chem. (1993) In press REFERENCE 2 (bases 1 to 3651) AUTHORS Tenhunen,J., Salminen,M., Lundstrom,K., Kiviluoto,T., Savolainen,R. and Ulmanen,I. TITLE Genomic organization of the human catechol O-methyltransferase gene and its expression from two distinct promoters JOURNAL Eur. J. Biochem. 223 (3), 1049-1059 (1994) PUBMED 8055944 REFERENCE 3 (bases 1 to 3651) AUTHORS Gastier,J.M., Brody,T., Pulido,J.C., Businga,T., Sunden,S., Hu,X., Maitra,S., Buetow,K.H., Murray,J.C., Sheffield,V.C., Boguski,M., Duyk,G.M. and Hudson,T.J. TITLE Development of a screening set for new (CAG/CTG)n dynamic mutations JOURNAL Genomics 32 (1), 75-85 (1996) PUBMED 8786123 REFERENCE 4 (bases 1 to 3651) AUTHORS Tenhunen,J. TITLE Direct Submission JOURNAL Submitted (22-SEP-1993) Tenhunen J., Orion-Farmos Pharmaceuticals, Valimotie 7, Helsinki, Finland FEATURES Location/Qualifiers source 1..3651 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" intron 1..984 exon 985..1074 intron 1075..1340 promoter 1120..1490 CDS join(1341..1629,1765..1958,2246..2377,2839..3039) /codon_start=1 /product="catechol O-methyltransferase" /protein_id="CAA81263.1" /db_xref="GI:403304" /db_xref="GOA:P21964" /db_xref="InterPro:IPR000051" /db_xref="UniProt/Swiss-Prot:P21964" /translation="MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQ PIHNLLMGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDA VIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKD KVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLA DNVICPGAPDFLAHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGPGSEAGP" exon 1341..1629 misc_signal 1341..1343 misc_signal 1491..1493 intron 1630..1764 exon 1765..1958 intron 1959..2245 exon 2246..2377 intron 2378..2838 exon 2839..3304 misc_signal 3037..3039 polyA_signal 3305..3310 ORIGIN 1 agtattgctg ttcagatagc ctttatttgg gtatatattc tacactgttt ttaaatatgg 61 agagtaacca aaatggccca ttatctgacc acacaaatac tagtagtcat tatagataaa 121 ccatagcaga taaataatag taaacaaagc aacaggctgt gtcattggaa atccccacca 181 tgaagaaagg agcaaggtga aaacttctgg ctgcttcagg tcatgcatgg tccctctcca 241 ccatcgttcc ccctgtcatc ttcctgccag aataaggacc ctggtacctt agggaagcac 301 catctcttgt tttttcccca cgagccctgt gggtcatggc acgtcctgcc ccgctgggaa 361 aacacagtgg gccacgggtt tccctgcagg cctggaccct tcccaagggt agcagcagaa 421 ggcagcacga ttcccactcc tgcagctgtg acagggcacc cccactgtca ctgagccctg 481 caccgggttc catcacctgc tcggggctct gcctttggcc ttttcctgtg aactgcatgt 541 tggccactgt acctatctgt ctctcatctt tttttcttac gggtttgggt atgttcttgg 601 taaaccagcc cttggtctta cacatcattt ccaaggtact aaggactctt caggggaaat 661 acaacttgag cagagtggtt ccctcctctt gtggttcaca aggtgcaggt gcacacacac 721 ataccacagg gcagtgtgac aggaccagag actgcccctg gggtccctgg ctgggggaca 781 ctagtaggga tgtcccttgc ctctctgagg ccttctgctg tctcttctga ggccggaaag 841 gcgaagcact gccctcgccc tgctagggaa ggctcaggcc aggctggccc tatccgggga 901 aggggctcag gtatctggac cttggtcatc gccaggttag ggtttatgtt gatgattatc 961 caaaggcaaa attgatttcc acagaaataa catctgcttt gctgccgagc cagaggagac 1021 cccagacccc tcccgcagcc agagggctgg agcctgctca gaggtgcttt gaaggtgagt 1081 tggccaacgg aagccggggc agtgccaggg tgggacagaa gaggcacaca cctgctctgt 1141 ctacccgagg gcaccagagg gcacgagaag gctggctccc tggcgctgac acgtcaggca 1201 actgaggcac aaggctggca tttctgaacc ttgcccctct gcgaacacaa gggggcgatg 1261 gtggcactcc aagcaaaggg gcgtgtgggt gctgcaggag gagcacagag cactggcgcc 1321 cctcccctcc cgccctgcag atgccggagg ccccgcctct gctgttggca gctgtgttgc 1381 tgggcctggt gctgctggtg gtgctgctgc tgcttctgag gcactggggc tggggcctgt 1441 gccttatcgg ctggaacgag ttcatcctgc agcccatcca caacctgctc atgggtgaca 1501 ccaaggagca gcgcatcctg aaccacgtgc tgcagcatgc ggagcccggg aacgcacaga 1561 gcgtgctgga ggccattgac acctactgcg agcagaagga gtgggccatg aacgtgggcg 1621 acaagaaagg ttggggttcc gggccagcag gtgctcagct ctgggacagg gacccaggac 1681 caggcatcaa atcccgtgcc tggggatcca agttcccctc tctccacctg tgctcacctc 1741 tcctccgtcc ccaaccctgc acaggcaaga tcgtggacgc cgtgattcag gagcaccagc 1801 cctccgtgct gctggagctg ggggcctact gtggctactc agctgtgcgc atggcccgcc 1861 tgctgtcacc aggggcgagg ctcatcacca tcgagatcaa ccccgactgt gccgccatca 1921 cccagcggat ggtggatttc gctggcgtga aggacaaggt gtgcatgcct gacccgttgt 1981 cagacctgga aaaagggccg gctgtgggca gggcgggcat gcgcactttg atcctcccca 2041 ccaggtgttc acaccacgtt cactgaaaac ccactatcac cagggtcatc ccagaaccct 2101 aaagaaaact gatgaatgct tgtatgggtg tgtaaagatg gcctcctgtc tgtgtgggcg 2161 tgggcactga caggcgctgt tgtataggtg tgtagggatg gcctcctgtc tgtgaggacg 2221 tgggcactga caggcgctgt tccaggtcac ccttgtggtt ggagcgtccc aggacatcat 2281 cccccagctg aagaagaagt atgatgtgga cacactggac atggtcttcc tcgaccactg 2341 gaaggaccgg tacctgccgg acacgcttct cttggaggtg agccccaacc aggatggcat 2401 ccgtgccagc tgctgcccag agcccattca gtcagcctca gcctctccaa agagccaggc 2461 attccagtag agccctgtgt ggacacagct cgctctggag gcaccacctg aggtctggga 2521 gtgtggggga ctgaggaggc cctgtggtgg gtggagatgg gtggggagct gggccagggg 2581 ctggctgggt ggcctgttgg gaactgggga gccaagcggt ccctgtcctc acggggccca 2641 tgttctgaag gtggcaccca agtcttgtac agtcctttcc tgcaggagtc acgctgggca 2701 ggaagtggaa acctggcccc aggggctagg cacaggcagt ggtgccgtgg cctagtgagg 2761 agcacccatc ctggtttggg gcaggttctc tgggcacctc tgacctctca cctcccccac 2821 cccccggtct gtttgcagga atgtggcctg ctgcggaagg ggacagtgct actggctgac 2881 aacgtgatct gcccaggtgc gccagacttc ctagcacacg tgcgcgggag cagctgcttt 2941 gagtgcacac actaccaatc gttcctggaa tacagggagg tggtggacgg cctggagaag 3001 gccatctaca agggcccagg cagcgaagca gggccctgac tgcccccccg gcccccctct 3061 cgggctctct cacccagcct ggtactgaag gtgccagacg tgctcctgct gaccttctgc 3121 ggctccgggc tgtgtcctaa atgcaaagca cacctcggcc gaggcctgcg ccctgacatg 3181 ctaacctctc tgaactgcaa cactggattg ttctttttta agactcaatc atgacttctt 3241 tactaacact ggctagctat attatcttat atactaatat catgttttaa aaatataaaa 3301 tagaaattaa gaatctaaat atttagatat aactcgactt agtacatcct tctcaactgc 3361 cattcccctg ctgcccttga cttgggcacc aaacattcaa agctcccctt gacggacgct 3421 aacgctaagg gcggggccct agctggctgg gttctgggtg gcacgcctgg cccactggcc 3481 tcccagccac agtggtgcag aggtcagccc tcctgcagct aggccagggg cacctgttag 3541 ccccatgggg acgactgccg gcctgggaaa cgaagaggag tcagccaagc attcacacct 3601 ttctgaccaa gcaggcgctg gggacaggtg gacccgcagc agcaccagcc c //